Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits.
Identifieur interne : 001885 ( Main/Exploration ); précédent : 001884; suivant : 001886Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits.
Auteurs : Bart L. Haagmans [Pays-Bas] ; Judith M A. Van Den Brand [Pays-Bas] ; Lisette B. Provacia [Pays-Bas] ; V Stalin Raj [Pays-Bas] ; Koert J. Stittelaar [Pays-Bas] ; Sarah Getu [Pays-Bas] ; Leon De Waal [Pays-Bas] ; Theo M. Bestebroer [Pays-Bas] ; Geert Van Amerongen [Pays-Bas] ; Georges M G M. Verjans [Pays-Bas] ; Ron A M. Fouchier [Pays-Bas] ; Saskia L. Smits [Pays-Bas] ; Thijs Kuiken [Pays-Bas] ; Albert D M E. Osterhaus [Pays-Bas]Source :
- Journal of virology [ 1098-5514 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Appareil respiratoire (virologie), Coronavirus du syndrome respiratoire du Moyen-Orient (croissance et développement), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Cricetinae, Excrétion virale, Femelle, Infections à coronavirus (anatomopathologie), Infections à coronavirus (virologie), Lapins, Maladies asymptomatiques, Modèles animaux de maladie humaine, Poumon (anatomopathologie), Poumon (virologie), Souris.
- MESH :
- anatomopathologie : Infections à coronavirus, Poumon.
- croissance et développement : Coronavirus du syndrome respiratoire du Moyen-Orient.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Appareil respiratoire, Infections à coronavirus, Poumon.
- Animaux, Cricetinae, Excrétion virale, Femelle, Lapins, Maladies asymptomatiques, Modèles animaux de maladie humaine, Souris.
English descriptors
- KwdEn :
- Animals, Asymptomatic Diseases, Coronavirus Infections (pathology), Coronavirus Infections (virology), Cricetinae, Disease Models, Animal, Female, Lung (pathology), Lung (virology), Mice, Middle East Respiratory Syndrome Coronavirus (growth & development), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Rabbits, Respiratory System (virology), Virus Shedding.
- MESH :
- growth & development : Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- pathology : Coronavirus Infections, Lung.
- virology : Coronavirus Infections, Lung, Respiratory System.
- Animals, Asymptomatic Diseases, Cricetinae, Disease Models, Animal, Female, Mice, Rabbits, Virus Shedding.
Abstract
The ability of Middle East respiratory syndrome coronavirus (MERS-CoV) to infect small animal species may be restricted given the fact that mice, ferrets, and hamsters were shown to resist MERS-CoV infection. We inoculated rabbits with MERS-CoV. Although virus was detected in the lungs, neither significant histopathological changes nor clinical symptoms were observed. Infectious virus, however, was excreted from the upper respiratory tract, indicating a potential route of MERS-CoV transmission in some animal species.
DOI: 10.1128/JVI.00661-15
PubMed: 25810539
Affiliations:
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Le document en format XML
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<author><name sortKey="Getu, Sarah" sort="Getu, Sarah" uniqKey="Getu S" first="Sarah" last="Getu">Sarah Getu</name>
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<author><name sortKey="De Waal, Leon" sort="De Waal, Leon" uniqKey="De Waal L" first="Leon" last="De Waal">Leon De Waal</name>
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<author><name sortKey="Bestebroer, Theo M" sort="Bestebroer, Theo M" uniqKey="Bestebroer T" first="Theo M" last="Bestebroer">Theo M. Bestebroer</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Asymptomatic Diseases</term>
<term>Coronavirus Infections (pathology)</term>
<term>Coronavirus Infections (virology)</term>
<term>Cricetinae</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Lung (pathology)</term>
<term>Lung (virology)</term>
<term>Mice</term>
<term>Middle East Respiratory Syndrome Coronavirus (growth & development)</term>
<term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term>
<term>Rabbits</term>
<term>Respiratory System (virology)</term>
<term>Virus Shedding</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Appareil respiratoire (virologie)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (croissance et développement)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term>
<term>Cricetinae</term>
<term>Excrétion virale</term>
<term>Femelle</term>
<term>Infections à coronavirus (anatomopathologie)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Lapins</term>
<term>Maladies asymptomatiques</term>
<term>Modèles animaux de maladie humaine</term>
<term>Poumon (anatomopathologie)</term>
<term>Poumon (virologie)</term>
<term>Souris</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Lung</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Appareil respiratoire</term>
<term>Infections à coronavirus</term>
<term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Lung</term>
<term>Respiratory System</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Asymptomatic Diseases</term>
<term>Cricetinae</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Mice</term>
<term>Rabbits</term>
<term>Virus Shedding</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cricetinae</term>
<term>Excrétion virale</term>
<term>Femelle</term>
<term>Lapins</term>
<term>Maladies asymptomatiques</term>
<term>Modèles animaux de maladie humaine</term>
<term>Souris</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The ability of Middle East respiratory syndrome coronavirus (MERS-CoV) to infect small animal species may be restricted given the fact that mice, ferrets, and hamsters were shown to resist MERS-CoV infection. We inoculated rabbits with MERS-CoV. Although virus was detected in the lungs, neither significant histopathological changes nor clinical symptoms were observed. Infectious virus, however, was excreted from the upper respiratory tract, indicating a potential route of MERS-CoV transmission in some animal species. </div>
</front>
</TEI>
<affiliations><list><country><li>Pays-Bas</li>
</country>
<region><li>Hollande-Méridionale</li>
</region>
<settlement><li>Rotterdam</li>
</settlement>
</list>
<tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name>
</region>
<name sortKey="Bestebroer, Theo M" sort="Bestebroer, Theo M" uniqKey="Bestebroer T" first="Theo M" last="Bestebroer">Theo M. Bestebroer</name>
<name sortKey="De Waal, Leon" sort="De Waal, Leon" uniqKey="De Waal L" first="Leon" last="De Waal">Leon De Waal</name>
<name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A M" last="Fouchier">Ron A M. Fouchier</name>
<name sortKey="Getu, Sarah" sort="Getu, Sarah" uniqKey="Getu S" first="Sarah" last="Getu">Sarah Getu</name>
<name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name>
<name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name>
<name sortKey="Provacia, Lisette B" sort="Provacia, Lisette B" uniqKey="Provacia L" first="Lisette B" last="Provacia">Lisette B. Provacia</name>
<name sortKey="Raj, V Stalin" sort="Raj, V Stalin" uniqKey="Raj V" first="V Stalin" last="Raj">V Stalin Raj</name>
<name sortKey="Smits, Saskia L" sort="Smits, Saskia L" uniqKey="Smits S" first="Saskia L" last="Smits">Saskia L. Smits</name>
<name sortKey="Stittelaar, Koert J" sort="Stittelaar, Koert J" uniqKey="Stittelaar K" first="Koert J" last="Stittelaar">Koert J. Stittelaar</name>
<name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name>
<name sortKey="Van Den Brand, Judith M A" sort="Van Den Brand, Judith M A" uniqKey="Van Den Brand J" first="Judith M A" last="Van Den Brand">Judith M A. Van Den Brand</name>
<name sortKey="Verjans, Georges M G M" sort="Verjans, Georges M G M" uniqKey="Verjans G" first="Georges M G M" last="Verjans">Georges M G M. Verjans</name>
</country>
</tree>
</affiliations>
</record>
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